Working with Auto-Layout fulltime for 2 months assured me that the technology is actually working. You can use it exclusively instead of autoresizing now. I am glad to be able to say that about an Apple technology. That is not always the case these days.
Sometimes you have to use a trick or two, but the results are worth it (example: Instead of using setFrame: for dynamically changing the bounds of a view, you should change the constant of the corresponding layout constraint. The welcoming side effect: you can animate that!)
Be sure however to set view.translatesAutoresizingMaskIntoConstraints to NO. Otherwise you might end up with lots of conflicts. The translation of autoresize masks is a bit useless, if you ask me. Either you use Auto-Layout or you don't.